Antibodies to Commonly Circulating Viral Pathogens Modulate Serological Response to Severe Acute Respiratory Syndrome Coronavirus 2 Infection

The purpose of this study was to determine the seropositivity circulating viral pathogens and their association with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity. In a cross-sectional design, inhabitants (aged 10–60 years) slum surrounding non-slum areas Dhaka Chattogram Metropolitan cities in Bangladesh were enrolled from October 2020 February 2021. Antibodies SARS-CoV-2, influenza B, parainfluenza, syncytial virus (RSV), human HKU1 (HCoV-HKU1), dengue chikungunya viruses determined plasma. SARS-CoV-2 other assessed using multi-variate logistic regression model. Seroprevalence RSV, dengue, chikungunya, HCoV-HKU1 parainfluenza 68.3%, 98%, 50.0%, 16.5%, 15.5%, 3.36% 0.0%, respectively. Individuals seropositive for RSV had lower odds (OR = 0.60; 95% CI= 0.49, 0.73) compared RSV-seronegative individuals. Conversely, higher observed participants (OR= 1.73; CI 1.14, 2.66, only slum) or 1.48; 1.11, 1.95) seronegative counterparts. findings indicated that exposure vector-borne enhance, while antibodies decrease, serological response SARS-CoV-2.